In 1992 she achieved breakout success with her role as Internal Affairs Detective Sergeant Lorna Cole in the 1992 action film Lethal Weapon 3 opposite Mel Gibson. The movie was a box office success, grossing over $320 million worldwide. In later years she had major roles in a number of box office hits and critically successful movies. In 1993 she starred opposite Clint Eastwood in the thriller film In the Line of Fire, directed by Wolfgang Petersen. In 1995 Petersen cast her in in the medical disaster film Outbreak alongside Dustin Hoffman. The film also had box office success, grossing $189 million worldwide. Also in 1995, she appeared in another box office hit, Get Shorty, a crime-comedy directed byBarry Sonnenfeld. In 1996 she starred in the romantic comedy Tin Cup with Kevin Costner, and reunited with her Lethal Weapon co-star Mel Gibson in the crime thriller Ransom, directed by Ron Howard. In 1998, she appeared and reprised her role as Lorna Cole in Lethal Weapon 4, the final film in the Lethal Weapon series, reuniting with all the original cast members of the Lethal Weapon series.